Category: Doctor

The Contribution of Mikhail Blagosklonny in Biogerontolgy

Mikhail Blagosklonny is an oncologist who conducts researches on health issues relating to aging and cancer. Oncology is that discipline of medicine that deals with the study of prevention, diagnosis, and prevention of cancer diseases. Blagosklonny has researched on biogerontology and anti-aging drugs.

Aging is the persistence of growth stimulated by beckoning pathways such as Target of Rapamycin, TOR. Most people believe that it is caused by a failure of maintenance which further causes more molecular injury. However, aging is not caused by the buildup of microscopic damage or by accidental injury of any kind in the body. Mikhail Blagosklonny articulated a hypothesis about the role of TOR signaling in aging. Aging can be treated by use of rapamycin together with other rapalogs as predicted by the TOR-centric model. Pathways that trigger growth in the body of humans operate on inertia even when completion of advancement growth has occurred. The TOR changes quiescent cells into senescent cells without involving any form of molecular impairment. The TOR pathway links to age-related diseases. It is the same path that stimulates the developmental growth that leads to aging and its related diseases. View Mikhail’s profile on Google Scholar

Over-simulation is known to cause growth in functions such as glycogenesis by liver cells, secretion by fibroblasts, aggregation by Platelets, inflammation by neutrophils, bone resorption by osteoclasts and phagocytosis by macrophages. However, these functions get lost in terminal aging. The loss of function results from the initial hyperfunction. Cellular hyperfunction is a major sign of aging. Sometimes the intake of hypertensive drugs can slow down the pathways signaling the hyperfunction and in the eventuality, end up preventing other age-related diseases. Examples of these drugs include angiotensin 2 and inhibitors of beta-adrenergic. Metformin is another drug which obstructs the TOR pathway. This results in prevention of premature menopause in women, lengthened life span, and reduced chances of cancers all which are related to aging.

Loss of homeostasis or the ARD, age-related diseases reduces the lifespan of humans in protected environments. Fortunately, postponement of this condition is possible by genetic manipulation, drugs and calorie restriction which deactivate the mTOR pathway.

The approval of Rapamycin also known as Sirolimus for clinical use occurred in 2006, and its use began in the same year. This drug is recommended for treating cancer, but recently it has been identified as a life extension medicine. Aging comes with several diseases, and this anti-aging drug has been approved as safe for use as a daily dose since it is non-toxic. The drug also contains bone-sparing and anti-tumor imitating side effects. The use of rapamycin not only treats aging but also extends the human lifespan and health span by preventing them from diseases. Rapamycin is used to treat autoimmunity, osteoporosis, cancer, Alzheimer, cardiovascular illnesses and metabolic disorders. Rapamycin is the most useful anti-aging drug as it not only treats the mentioned diseases but rather boosts the immunity. In fact, it is described to revive the immune system from old type to that of an infant. The drug works by removing hyper-immunity and therefore does not suppress the immunity of patients.

Know more: http://gettingstronger.org/tag/mikhail-blagosklonny/

Has MB2 Dental Solutions Revolutionized the Dental industry? – Find out

Chris Villanueva, the CEO of MB2 Dental Solutions, started off as any average dentist in the community. After graduating from dental school, he ventured into the obvious dentistry practices- group and individual. He realized that both models stripped the profession of its integrity. As such, Chris decided to create a platform where dentists could practice their profession while reaping its benefits. He founded MB2 Dental Solutions with a vision of combining the positive features of private and corporate practices while alleviating the negatives of each. Unlike traditional dental management networks that are rather profit-oriented, Chris has cultivated a culture of autonomy, personal growth, and support. Some other progressive business cultures adopted by the company include:

  • MB2 keeps tabs of the new practice standards and trends
  • A youthful culture that has practical experience and upholds excellence
  • Create a learning environment
  • Commitment to helping practitioners retain control over their practice
  • A technologically advanced firm that provides prompt services

What is different about MB2?

Having practiced as a dental director, an associate dentist trainer and associate dentist, mentor, and advocate for the doctor-oriented practice model, Dr. Chris had gained considerable insight into the provider and business side of the dental practice. As such, he looked to create a platform that allowed both private and corporate practitioners could collaborate without compromising the integrity of the profession. Dr. Villanueva figured that, if the doctors worked together, they could accomplish more than when they worked in their private practices. By creating an avenue to empower practitioners, physicians could improve the patient’s experience. So far, he has accomplished most of the objectives with a network of over seventy affiliations in six states and more than 533 staff members. He accredits most of the success to maintaining a close-knit leadership, investing in people, and embracing the role technology plays in the dental industry. Dr. Chris notes that, while other resources like having cut-throat marketing ideas and patented software contribute to the success of a firm, what matters most in creating a community-based dental practice is hiring the right individual for the job. Additionally, his confidence in the company’s IT function to customize home-made reporting software encourages other businesses to follow suit. Most companies rely on ready-made software that often doesn’t capture all its needs. MB2 Dental Solutions’ software Jarvis boasts of a horde of capabilities, giving it an edge over the competition. Visit epodcastnetwork.com to know more.

His Personal Life

Dr. Chris Villanueva was born in Ohio but spent most of his early life in South America and Asia. He is married to Carol, a physician, who is also the mother of their four children. Dr. Chris enjoys mentoring young dentists alongside his executive responsibilities.

Putting a Smile On The Face of a Child

There has been a recent account set up by Avi Weisfogel for Operation Smile. The account is on the popular online avenue, GoFundMe. This is a way that visitors can donate money without mailing it or calling someone with a credit card number. Operation Smile is a program that has been established across the world to help with surgical dental procedures for children. Some of the procedures that are done are for cleft lips and other conditions of the mouth that affect the appearance of the child and the function of the mouth.

A $2,000 goal has been declared by Weisfogel. He recently gave an interview about the program and the support that is needed to help give children the beautiful and healthy smiles that they deserve. The program goes hand in hand with doctors and dentists in order to help with the medical costs and procedures. Local healers are used so that there isn’t a language barrier between the parents, children and doctors. One of the first places that the organization worked was the Philippines. Since then, children across the world have been helped by Operation Smile.

Avi Weisfogel is the owner of a New Jersey dental office and is a Dental Sleep Masters Instructor. The goal of his business is to work with dentists who are trying to help patients with sleep. He has an understanding of sleep apnea and how dental issues can affect the condition.

Since 2010, Avi Weisfogel has been working with adults and children in order to help them sleep better. It could be in the form of resolving narrow airways to teaching about health conditions that include diabetes and heart disease. His latest effort with Operation Smile is only another way that Weisfogel wants to help children with dental services.