Archives: July 2017

Oncotarget, Redefining Biomedical Research

Oncotarget, Redefining Biomedical Research

Oncortarget is an open access peer reviewed journal that publishes the latest cancer research. The journal focuses specifically on the field of cancer research publishing paradigm shifting articles which encompass the broad and complex field of oncology. It was started in 2010 in response to the need to translate the massive accumulation of knowledge on oncogenes, oncoproteins, cellular processes such as proliferation and autophagy, signal transduction and the function and dysfunction of cells from basic research to their clinical applications reverse. The journal’s editors in chief are Andrei V. Gudkov and Mikhail Blagosklonny, two highly qualified scientists at the Roswell Park Centre Institute (RPCI) dealing with cancer research and treatment. Oncotarget provides researchers with an opportunity to publish mistakenly rejected papers together with a rebuttal letter for the peer reviews received on the previous journal. This increases opportunity scientist have to make their impact on the field of cancer research. During 2015-2016 Oncotarget had an impact factor score of 5.008 meaning the publications on the journal had been cited over 10,000 times during that period.

In line with their mission statement to “make scientific results rapidly and widely available,” the journal publishes weekly papers available for free and may be printed on special order. From 75 papers in 2010, the journal increased publication to 1330 in 2014, 3000 in 2015 and now over 8000 from figures in 2016. This represents a wealth of knowledge that can be used in the treatment of one of the deadliest disease affecting people in the 21st century. The study of oncology has been a very difficult journey throughout the years, it then follows that the more knowledge available the faster the progress towards better therapy and management of the disease will be. The journal also relates the various branches of biomedical sciences in the prevention of diseases and the improvement of quality life. A paper published on Oncotarget on the effect of nutrition on cellular rejuvenation, research of which is still ongoing, found that diets which increase lifespan do not also enhance the reproductive process necessary for cellular rejuvenation. Apparently, an increase of lifespan occurs at the expense of growth and reproduction (Huebbe, Schloesser&Rimbach 2015). These are some of the paradigm shifting research that can be found on the journal. Visit https://www.crunchbase.com/person/mikhail-blagosklonny to read more on this and other up to date research papers and articles.

Vincent Parascandola, The Successful Financial Advisor

Financial management is a significant field especially for individuals who tend to possess a lot of money. Financial advisors play a huge role in ensuring that the money of clients is managed properly so as to prevent any cases of loss being encountered, or situations where bad business decisions are made. Insurance of people’s finance is likewise important since it helps to secure the funds and assets that are owned by those who are willing to pay for the financial management services.

Vincent Parascandola is a guru in this field of finance, and he is considered by most of his peers to be well equipped with the knowledge that helps him to serve his clients in a manner that provides best results. Vincent Parascandola has proved himself to be a force that should be respected considering the success that follows him wherever he goes.

Currently, he is the Senior Executive Vice President of AXA Advisors and getting to that point was not a simple walk in the park. For Vinny, he had to work hard for an extended period, until he was assigned the role of leading one of the largest insurance companies in the world. Vinny began his career in 1978, and as time progressed, he ensured that the odds of life favored him by putting his best skills and talent to work. Vinny has worked in various organizations, and the most interesting thing is that he has always been assigned positions that relate to management of the companies. For Vinny, he believes that talent is what has enabled him to become successful.

Vinny began as an agent in the financial industry while working at Prudential. While at the organization, he was recognized as the National Rookie of the year, which indicates that his passion for finance is deep inside him. He had joined Prudential after completing his studies in Bachelor of Science. However, Vinny fully committed himself in financial matters, and after working at Prudential, he moved to MONY life where he stayed for 13 years. Afterward, he transferred to AXA advisors as he believed that such a huge organization would provide him with a greater challenge in life which is something that he was yearning to get.

Hollywood Artists Finding Lasting Joy and Fulfillment at Kabbalah Centre

When Madonna joined Kabbalah, it seemed like she was the only non-Jew member interested with the Jewish Mysticism. However, soon after she joined, many other Hollywood stars including Britney Spear, Paris Hilton, Sandra Bernhard, the late Marylin Monroe, the late Sammy Davis, and the late Elizabeth Taylor showed their fascination with the Jewish tradition, Kabbalah.

 

Why Join Kabbalah In Such Large Numbers?

This mass fascination brought about several questions. Why are they joining and converting to Judaism has remained the major issue? When the different artists were asked, they gave different reasons. For Paris Hilton, joining Kabbalah helped her settle after breaking up with Nick Carter. On joining, she was given a Kabbalah bracelet that has helped her find peace. This might hold some truth as the Kabbalah Center Website explains how the ancient wisdom is essential in creating lasting fulfillment and joy.

 

On his side, Sammy Davis joined Kabbalah to become part of a 5,000-year-old tradition. He stated that Jews had been victims of oppression since times in history, and as a result, they have become stronger. As an African American, Sammy felt that just like the Jews, Africans had undergone the same fate. As a result, he felt deeply connected with this Jewish Mysticism.

 

Madonna stated that she joined Kabbalah because it instills a helping character to its followers. On her side, Elizabeth Taylor became interested in helping people to the point of offering herself in exchange for the 100 Israelis held as hostages at The Entebbe Airport in 1976. Other artists such as Britney Spears joined Kabbalah after she was introduced by Madonna, a long time friend and learn more about Kabbalah.

 

About Kabbalah Centre

The Kabbalah Centre is the largest international organization focusing on dissemination of Jewish wisdom. The organization was established in 1922 by Rav Yehuda Ashlag with a purpose of dissemination wisdom, which in turn helps people improve their lives. The Kabbalah Centre is located in Los Angeles, California, and it provides Zohar and Kabbalistic teachings and more information click here.

 

The Kabbalah Centre has a multi-ethnic staff that offers Kabbalistic studies to their student across the world. The knowledge is disseminated in two major ways either through physical attendance at their branch offices across the world or through their online platform. Joining the Kabbalah Centre doesn’t require Hebrew or Jewish background. Moreover, religious affiliations such Christians, Muslims, Buddhists, and Judaists can join Kabbalah Centre as it is not an alternative to any religion.

The Contribution of Mikhail Blagosklonny in Biogerontolgy

Mikhail Blagosklonny is an oncologist who conducts researches on health issues relating to aging and cancer. Oncology is that discipline of medicine that deals with the study of prevention, diagnosis, and prevention of cancer diseases. Blagosklonny has researched on biogerontology and anti-aging drugs.

Aging is the persistence of growth stimulated by beckoning pathways such as Target of Rapamycin, TOR. Most people believe that it is caused by a failure of maintenance which further causes more molecular injury. However, aging is not caused by the buildup of microscopic damage or by accidental injury of any kind in the body. Mikhail Blagosklonny articulated a hypothesis about the role of TOR signaling in aging. Aging can be treated by use of rapamycin together with other rapalogs as predicted by the TOR-centric model. Pathways that trigger growth in the body of humans operate on inertia even when completion of advancement growth has occurred. The TOR changes quiescent cells into senescent cells without involving any form of molecular impairment. The TOR pathway links to age-related diseases. It is the same path that stimulates the developmental growth that leads to aging and its related diseases. View Mikhail’s profile on Google Scholar

Over-simulation is known to cause growth in functions such as glycogenesis by liver cells, secretion by fibroblasts, aggregation by Platelets, inflammation by neutrophils, bone resorption by osteoclasts and phagocytosis by macrophages. However, these functions get lost in terminal aging. The loss of function results from the initial hyperfunction. Cellular hyperfunction is a major sign of aging. Sometimes the intake of hypertensive drugs can slow down the pathways signaling the hyperfunction and in the eventuality, end up preventing other age-related diseases. Examples of these drugs include angiotensin 2 and inhibitors of beta-adrenergic. Metformin is another drug which obstructs the TOR pathway. This results in prevention of premature menopause in women, lengthened life span, and reduced chances of cancers all which are related to aging.

Loss of homeostasis or the ARD, age-related diseases reduces the lifespan of humans in protected environments. Fortunately, postponement of this condition is possible by genetic manipulation, drugs and calorie restriction which deactivate the mTOR pathway.

The approval of Rapamycin also known as Sirolimus for clinical use occurred in 2006, and its use began in the same year. This drug is recommended for treating cancer, but recently it has been identified as a life extension medicine. Aging comes with several diseases, and this anti-aging drug has been approved as safe for use as a daily dose since it is non-toxic. The drug also contains bone-sparing and anti-tumor imitating side effects. The use of rapamycin not only treats aging but also extends the human lifespan and health span by preventing them from diseases. Rapamycin is used to treat autoimmunity, osteoporosis, cancer, Alzheimer, cardiovascular illnesses and metabolic disorders. Rapamycin is the most useful anti-aging drug as it not only treats the mentioned diseases but rather boosts the immunity. In fact, it is described to revive the immune system from old type to that of an infant. The drug works by removing hyper-immunity and therefore does not suppress the immunity of patients.

Know more: http://gettingstronger.org/tag/mikhail-blagosklonny/

Securus Technologies Fighting the War on Drugs

Drugs inside the prison puts every person behind those walls in immediate danger. Besides the fact that inmates already outnumber the corrections officers 5:1 in most cases, drugs make an inmate go from manageable to uncontrollable in the blink of an eye. An inmate experimenting with heroin or crack for the first time could become so violent that they put the entire prison population in danger. This is only one of the reasons we are working hard to eliminate drugs from getting into our facility.

 

Inmates are having an easier time getting drugs in the prison than they would on the streets, and this has my superiors wanting results today to crack down on the flow of contraband into the jail. We have increased our searches of the inmate’s cells, we have set up searches in the visitor center, we even monitor the calls the inmates are making on the telephone.

 

Securus Technologies was instrumental in helping us to control the flow of drugs into the jail. The company has their inmate call monitoring system currently installed in over 2,500 jails, and they have become a powerful tool in helping to keep the inmates from getting drugs. The LBS software will listen to the inmates talking on the phone and can isolate specific chatter and then alert officers to the calls. Now we are able to tackle the problem before it even gets to our facility.

 

My team has been alerted to calls where the inmates are talking about ways the outsiders can smuggle contraband into the visitor center. We heard one inmate talking about how easy it is to buy drugs from gang members in the yard. Our team even heard one inmate explaining the technique for coating a letter in a liquid drug so he could consume it to get his high.

 

Arthur Becker and His Investments

Arthur P. Becker is the Managing Member of Madison Partners. Madison deals with early stage Bio Tec and Real Estates. He has also previously served at the NASDAQ quoted company, NaviSite as the CEO. NaviSite offers colocation, application management, hosting and IT services to the United Kingdom and the United States markets. He worked at NaviSite until 2010 and later joined Zinio LLC. NaviSite was bought by Time Warner in 2011. At Zinio, he served as the Chairman and CEO from 2012 to 2015. Additionally, Becker has served as an advisor to a fashion company dubbed Vera Wang for seven years. He has also served as the director and VC of ClearBlue Technologies and a co-founder of Atlantic Investors. Check out angel.co for the details.

For five years now he has privately invested in technology and real estate industries. Becker’s interests in lands and buildings grew when in ZINIO and NaviSite. It was from there that he chose to venture into condominium expansion in Miami and New York. Currently, Arthur is working on building a luxury residential condominium in Tribeca and other several Town Houses in New York. Arthur finds the development stages of buildings fascinating. The design, construction, entitlements, marketing, and financing are some of the aspects of real estate that thrill Arthur Becker though he is most effective in coordination and organization of different expertise. Regarding bio tech, Becker has exposure in medicine though he has no training in it. The recent trends in treating cancer excite him.

According to The Real Deal, over time Becker has tried several businesses, others have failed, but he has been using those experiences as lessons. He started working as early as 16 when he joined Parks Department in one of the towns. He also had a construction company when in college. The company dealt with dis-assembling houses. Though he didn’t complete his graduate studies in business, he has been successful in his entrepreneurial career because of his intelligence, being flexible in strategy, listening to others and being informed at all times. The policy which one adopts should reflect the business vertical for it to succeed. Arthur adds that talent also plays a significant role in driving success.

See more: https://therealdeal.com/2017/03/28/the-condos-beckon-arthur-becker-going-it-alone-on-tribeca-boutique-project/

Whitney Wolfe – Bumble Master

Most retail outlet providers’ catalogs will agree that the Bumble BFF stands at the top. It is both inexpensive for the quality and durability that it offers and easy to place or remove. It makes Best Sellers Rank on numerous sites and ranks 4.5 stars. Most customers appreciate its easy dating that comes with a threaded leaf spring background font for easy profile recycling. It is also smaller than most apps but offers more dedicated capacity for media messaging.

Every year as of January 2007, top websites such as www.appsbest.com and www.whitneywolfe.com produce a list of the top apps for the previous and current year as well as what they foresee to be the growing trend into next year. Such information is widely released to the public and shows the quality-rated Bumble brands standing among the best this year. Two types particularly stand out in performance: They are the Bumble BFF and Tinder. The former comes with the 98% Multi-Pass Efficiency Rating and ranks five stars. Made in China, it costs no more than a free signup and has been around for nearly a year.

Read more on nytimes.com

For one, the dating app could explode and send fumes into your indoor love compartment as well as outside the app. App sound pops, crackles, snaps and bursting sounds are common, and scare first timers. A slight annoyance today can become a problem or emergency tomorrow if unchecked and thus allowed to grow. Be the smarter person, and do not allow this to be your experience. This business ranks at four stars by most serious companies and is an app of choice for long-term dating health and proper social prevention; it is seventh on the list but still no less in the top 11.

The same situation manifests itself here. I say that not using the proper engine oil or one of good quality, in addition to not ever performing engine oil maintenance on your vehicle, is deadly. In fact, that is a major understatement. That is why the Whitney Wolfe’s Bumble BFF is here. It is also rated one of the most precise in meet ups.

For more information about Whitney Wolfe, just click here.

Ricardo Tosto Reminds Investors of the CBE Quarterly Declarations in Brazil

In Brazil, there is an annual declaration that takes place to set and decide the guidelines of how the Brazilian investment will happen in the outside capital. They call it “Anual CBE.” There is also the three months CBE, which takes place during the rest of the year.For 2017, the votation and decision ended in 5, April, with some interesting differences from past years in the court. There are, however, still some leftover declarations that will take place for the rest of the year, só professionals in the country are aware that the decisions are not set in stone yet.According to the Central Bank of Brasil (BACEN), the failure on delivering the declarations in the predefined dates will result in charges of up to R$250.000,000, which translates to the American currency as around $75.000,000.His twitter account : https://twitter.com/ricardotosto01?lang=pt

Ricardo Tosto, an important personality in the decisions of 2017, gave his word about the declaration and the charged amount for those who do not meet the requirements in the period stipulated. The businessman stated that, nowadays, the declarations could even be given through the internet, which means that not meeting the deadlines are not an excuse of location anymore.The annual CBE declaration is obligatory for real individuals with domicils in the country or residing in the territory of Brazil, as well as the requirement of having some sort of title in the exterior market of any nature, including simple assets in the stock market or even properties.

The difference to the quarterly CBE declaration is that this one is restricted to those who have these assets on the exterior that equals or surpasses an amount of at least $100.000.000,00. It is a restrictive category but is very important to differentiate the duties of the large investors from the smaller ones.For this category, Ricardo Tosto remembers that the dates to be announced, throughout the year, your declarations, if you enter the category, are 30 of March, July, and September. The first two dates for the statement have already expired, and, by the time we are reaching the end of 2017, the time for the third and final quarterly announcement of the year will retake place.

Has MB2 Dental Solutions Revolutionized the Dental industry? – Find out

Chris Villanueva, the CEO of MB2 Dental Solutions, started off as any average dentist in the community. After graduating from dental school, he ventured into the obvious dentistry practices- group and individual. He realized that both models stripped the profession of its integrity. As such, Chris decided to create a platform where dentists could practice their profession while reaping its benefits. He founded MB2 Dental Solutions with a vision of combining the positive features of private and corporate practices while alleviating the negatives of each. Unlike traditional dental management networks that are rather profit-oriented, Chris has cultivated a culture of autonomy, personal growth, and support. Some other progressive business cultures adopted by the company include:

  • MB2 keeps tabs of the new practice standards and trends
  • A youthful culture that has practical experience and upholds excellence
  • Create a learning environment
  • Commitment to helping practitioners retain control over their practice
  • A technologically advanced firm that provides prompt services

What is different about MB2?

Having practiced as a dental director, an associate dentist trainer and associate dentist, mentor, and advocate for the doctor-oriented practice model, Dr. Chris had gained considerable insight into the provider and business side of the dental practice. As such, he looked to create a platform that allowed both private and corporate practitioners could collaborate without compromising the integrity of the profession. Dr. Villanueva figured that, if the doctors worked together, they could accomplish more than when they worked in their private practices. By creating an avenue to empower practitioners, physicians could improve the patient’s experience. So far, he has accomplished most of the objectives with a network of over seventy affiliations in six states and more than 533 staff members. He accredits most of the success to maintaining a close-knit leadership, investing in people, and embracing the role technology plays in the dental industry. Dr. Chris notes that, while other resources like having cut-throat marketing ideas and patented software contribute to the success of a firm, what matters most in creating a community-based dental practice is hiring the right individual for the job. Additionally, his confidence in the company’s IT function to customize home-made reporting software encourages other businesses to follow suit. Most companies rely on ready-made software that often doesn’t capture all its needs. MB2 Dental Solutions’ software Jarvis boasts of a horde of capabilities, giving it an edge over the competition. Visit epodcastnetwork.com to know more.

His Personal Life

Dr. Chris Villanueva was born in Ohio but spent most of his early life in South America and Asia. He is married to Carol, a physician, who is also the mother of their four children. Dr. Chris enjoys mentoring young dentists alongside his executive responsibilities.